NMRThe comprehensive suite of ultra high field NMR instrumentation within the DHMRI provides advanced capabilities in a unique setting for studying macromolecular structures and dynamics, protein complexes, molecular machines, ligand interactions, natural products and synthetic intermediates for biomedical and chemical research. The DHMRI NMR Laboratory is equipped with a Bruker Avance-III 950 MHz, a Bruker Avance-III 700 MHz NMR, a Bruker Avance-III 600 MHz NMR, and a Bruker Avance-III 400 MHz NMR spectrometer. The Bruker Avance-III 950 MHz has the highest commercially available magnetic field strength currently available. The three higher field instruments are also equipped with CryoProbes™ with cryogenically cooled receiver circuits to provide the ultimate sensitivity. The instruments are perfectly suited for small molecule, large molecule, and protein structure elucidation and larger scale structural folding characterization. Their high sensitivity makes complex two, three, and four dimensional nuclear correlation experiments feasible. The 400 MHz instrument is available for more broad ranging physical and chemical experiments such as molecular characterization of inorganic and organo-metallic compounds. All NMR probes are equipped with Z-gradients for diffusion experiments, and the 950 MHZ NMR also contains a probe with a triple axis gradient for small sample imaging experiments. The facility is also equipped with a variety of sample changers and an LC for application in separation, screening, and high throughput NMR. In addition, all instrumentation is internet accessible for remote operation and monitoring of experiments. |
950 MHz Spectrometer
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